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GLPG 0974
CAS No. 1391076-61-1
GLPG 0974( GLPG0974 )
Catalog No. M11618 CAS No. 1391076-61-1
GLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 110 | Get Quote |
|
| 10MG | 177 | Get Quote |
|
| 25MG | 356 | Get Quote |
|
| 50MG | 530 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGLPG 0974
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NoteResearch use only, not for human use.
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Brief DescriptionGLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM.
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DescriptionGLPG 0974 is a potent, selective free fatty acid receptor 2 (FFA2, GPR43) antagonist with IC50 of 95 nM; inhibits acetate-induced neutrophil migration strongly in vitro with IC50 of 27 nM; demonstrates ability to inhibit a neutrophil-based pharmacodynamic (PD) marker, CD11b activation-specific epitope [AE], in a human whole blood assay.Ulcer,Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsGLPG0974
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PathwayGPCR/G Protein
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TargetFFAR
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RecptorFFAR
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Research AreaOther Indications
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IndicationUlcer
Chemical Information
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CAS Number1391076-61-1
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Formula Weight484.995
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Molecular FormulaC25H25ClN2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (412.37 mM)
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SMILESO=C(O)CCCN(C([C@]1(C)N(C(C2=CSC3=CC=CC=C23)=O)CC1)=O)CC4=CC=CC(Cl)=C4
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Chemical Name4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pizzonero M, et al. J Med Chem. 2014 Dec 11;57(23):10044-57.
2. Sergeev E, et al. J Biol Chem. 2016 Jan 1;291(1):303-17.
3. Namour F, et al. Br J Clin Pharmacol. 2016 Jul;82(1):139-48.
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